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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PPP1R12A All Species: 21.21
Human Site: S588 Identified Species: 66.67
UniProt: O14974 Number Species: 7
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens O14974 NP_001137357.1 1030 115281 S588 G L Q K S L L S S T S T T T K
Chimpanzee Pan troglodytes XP_001163432 1030 115419 S588 G L Q K S L L S S T S T T T K
Rhesus Macaque Macaca mulatta XP_001086127 1029 115179 S588 G L Q K S L L S S T S T T T K
Dog Lupus familis XP_852025 1029 115190 S587 G L Q K S L L S S T S T T T K
Cat Felis silvestris
Mouse Mus musculus Q9DBR7 1029 114978 S588 G L Q R S L P S S T S T A A K
Rat Rattus norvegicus Q10728 1032 115264 S588 G L Q K S F L S S T S T T A K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90623 1004 111588 A587 G L Q K T L P A S A N T T T K
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6DRG7 1049 117303 K592 S L E P N N S K A W Q P S S Y
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 99.5 98.1 N.A. 93.7 94 N.A. N.A. 84.2 N.A. 73.5 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.5 99.7 99.3 N.A. 96.6 97.1 N.A. N.A. 91.1 N.A. 83.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 73.3 86.6 N.A. N.A. 66.6 N.A. 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 80 86.6 N.A. N.A. 86.6 N.A. 40 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 13 13 13 0 0 13 25 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 13 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 13 0 0 0 0 0 0 0 0 0 % F
% Gly: 88 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 75 0 0 0 13 0 0 0 0 0 0 88 % K
% Leu: 0 100 0 0 0 75 63 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 13 13 0 0 0 0 13 0 0 0 0 % N
% Pro: 0 0 0 13 0 0 25 0 0 0 0 13 0 0 0 % P
% Gln: 0 0 88 0 0 0 0 0 0 0 13 0 0 0 0 % Q
% Arg: 0 0 0 13 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 13 0 0 0 75 0 13 75 88 0 75 0 13 13 0 % S
% Thr: 0 0 0 0 13 0 0 0 0 75 0 88 75 63 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 13 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 13 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _